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関連する概念動画

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K
Aging01:26

Aging

179
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
179
Bone Disorders01:29

Bone Disorders

3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
Three Developmental Domains01:29

Three Developmental Domains

332
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
332
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

120
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
120
Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Updated: Sep 9, 2025

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
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三次元における生理学的老化

Fei Ma1, Ranjan Sen1

  • 1Gene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.

Trends in cell biology
|August 31, 2025
PubMed
まとめ
この要約は機械生成です。

遺伝子の発現と細胞機能に影響する 3次元 (3D) の染色体組織が老化によって変化します このレビューでは,3Dゲノム構造の年齢関連の変化と 老化と老化との関連を調査します.

キーワード:
3Dクロマチン構造老化する強化剤と促進剤の相互作用エピゲノム衰えること転写規制について

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Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
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関連する実験動画

Last Updated: Sep 9, 2025

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科学分野:

  • エピジェネティクスと分子生物学
  • ゲノミクスとバイオインフォマティクス
  • 細胞の老化と老年学

背景:

  • DNAメチル化やヒストンの改変などによる 進行的な衰退が加わります
  • 遺伝子の調節に欠かせない三次元 (3D) クロマチンの組織は,老化の未熟な側面である.
  • 染色体構成のキャプチャ技術は,コンパートメント,TAD,ループのような階層構造を明らかにします.

研究 の 目的:

  • 3Dクロマチン構造の年齢関連再構成に関する最近の発見をレビューする.
  • これらの構造変化が遺伝子転写と核構造に与える影響を強調する.
  • 老化と老化における3Dクロマチンの組織を比較し,共通と異なる特徴を特定する.

主な方法:

  • 3Dゲノム組織と老化に関する最近の研究の文献レビュー.
  • 染色体構成捕捉 (3C) ベースの技術のデータ分析.
  • 染色体構造に関する老化と老化の文脈の比較分析.

主要な成果:

  • 3Dクロマチンの構造は老化によって変化し,コンパートメント,TAD,ループなども変化します.
  • 遺伝子発現パターンの変化と細胞機能障害と相関しています.
  • 特定の核構造の変化は,年齢とともに観察される.

結論:

  • 3Dクロマチンの組織における年齢関連の変化は,細胞機能と生物の老化に大きく影響する.
  • これらの構造的動態を理解することは 老化メカニズムを解読し 介入策を策定する上で鍵となるものです
  • 3Dクロマチン組織は,老化と細胞老化において,共有され,異なる役割がある.