非高血圧集団における血圧と脳卒中のリスクとの関連性に対するHS-CRPの改変効果:前向きなコホート研究

Fanghua Liu¹, Xiaowei Zheng², Suwen Shen³

¹The First Department of Chronic Disease Prevention and Control, Baoshan District Center for Disease Control and Prevention, Shanghai, 201901, China.

Nutrition, metabolism, and cardiovascular diseases : NMCD

|August 31, 2025

まとめ

高感度C反応性タンパク質 (HS-CRP) は,正常な血圧と脳卒中リスクとの関連性を変化させます. 低血圧ではなく高血圧CRPの個体では,脳卒中のリスクが著しく増加した.

科学分野:

心血管伝染病学
バイオマーカーと病気のリスク
予防的な心臓科

背景:

血圧 (BP) と高感度C反応性タンパク質 (HS-CRP) は,脳卒中の危険因子として知られています.
血圧が正常な個体における脳卒中のリスクに対するBPとHS- CRPの組み合わせの影響は十分に理解されていません.

研究の目的:

血圧と脳卒中リスクの関係におけるHS-CRPの役割を調査する.
高血圧のない中国人成人の集団でこの関連性を調べる.

主な方法:

中国保健・退職長期研究 (CHARLS) の45歳以上の中国人成人を対象とした分析.
発症した脳卒中を9年間追跡した.
多変量コックス比例リスク回帰モデルは,HS-CRPレベルによって層分かれ,脳卒中リスクを評価するために使用されました.

主要な成果:

静脈動脈圧 (SBP),静脈動脈圧 (DBP),および平均動脈圧 (MAP) の上昇は,高いHS- CRPレベルを有する参加者においてのみ,脳卒中リスクの増加と関連していました.
高血圧CRP患者の間で,高血圧と脳卒中のリスクとの間には線形的な投与量反応関係が見られた.
高血圧と脳卒中リスクとの間に,HS- CRPレベルが低い個体では,有意な関連性が見られなかった.

結論:

高濃度のHS-CRPは,高血圧と関連した脳卒中のリスクを高めます.
HS-CRPは,高血圧による脳卒中のリスクが高い正常血圧の個人を特定する上で重要なバイオマーカーとして機能する.

キーワード:

血圧チャールズ HS-CRP について脳卒中

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