宿主-微生物群の交響における微生物の揮発性信号の解読

Andrea Dell'Olio¹, Franco Biasioli², Vincenzo Fogliano³

¹Food Quality and Design, Wageningen University & Research, Bornse Weilanden 9, Wageningen 6708 WG, The Netherlands; Sensory Quality Unit, Edmund Mach Foundation, Via Edmund Mach 1, San Michele all'Adige 38098, Italy.

Trends in endocrinology and metabolism: TEM

|August 31, 2025

まとめ

人間の腸内微生物群は,宿主の健康に影響を与える微生物の揮発性有機化合物 (mVOC) を生成します. ボラティロミクスはこれらの化合物を研究し腸内微生物の伝達と宿主信号伝達における役割を明らかにします

科学分野:

微生物学
メタボロミクス
人間の健康

背景:

人間の腸内微生物群はホストの健康と病気に大きな影響を与えます
研究は微生物分類から微生物代謝物の機能的役割の理解へと移行しています.
微生物の揮発性有機化合物 (mVOC) は腸の生態系における重要なシグナリング分子です.

研究の目的:

人間の腸内のmVOCの現在の理解をレビューする.
腸内微生物の代謝物の研究における揮発性化学の応用を強調する.
ホストと微生物の相互作用におけるmVOCのシグナル伝達と規制の役割を調査する.

主な方法:

腸のmVOCに関する既存の文献の包括的なレビュー.
in vitro,ex vivo,およびin vivoの volatilomicsのアプローチについての議論
微生物の揮発性代謝産物と機能を調査する研究の分析

主要な成果:

mVOCはバクテリアの伝達と宿主とのシグナル伝達に関与する.
ボラティロミクスは,mVOCを特定し,特徴づけるための強力なプラットフォームを提供します.
これらの化合物は宿主の代謝と生理学的プロセスを調節する可能性があります.

結論:

mVOCの理解は,腸内微生物群の機能を明らかにするために不可欠です.
これらの分子の生物学的意義を明らかにするために,統合されたボラティロミクスのアプローチは不可欠です.
mVOCに関するさらなる研究は,腸の健康と疾患管理に関する新しい洞察につながる可能性があります.

キーワード:

ホスト微生物通信腸の健康について微生物の揮発性有機化合物 (mVOC)ボラティロミクス

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