IVF/ICSI-ET治療を受けるカップルの精液パラメータと助産生殖結果に対する父親の体量指数の影響
Jing Yi Han1, Chen Yang1, Bing Nan Ren1
1Center for Reproductive Medicine, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, PR China.
Obesity research & clinical practice
|August 31, 2025
まとめ
父の体量指数 (BMI) は男性の生育能力と人工生殖技術 (ART) の結果に影響します. 男性の正常なBMIは,IVF/ICSI-ETサイクルにおける精子の質の改善,胚の発達,および妊娠率の上昇と関連しています.
科学分野:
- 生殖医学
- アンドロロジー
- 不妊 症 研究
背景:
- 父の要因は生殖の成功に大きく影響する.
- 助産生殖技術 (ART) の結果における父親の体量指数 (BMI) の役割については,さらなる調査が必要である.
- 精液のパラメータとARTの成功に対する父親の体重の影響を理解することは,受精治療の最適化に不可欠です.
研究 の 目的:
- 父のBMIと精液の品質の関連性を評価する.
- 体外受精/細胞内精子注射-胚移植 (IVF/ICSI-ET) の胚学的および臨床的結果に対する父親のBMIの影響を評価する.
- ARTを受けるカップルの妊娠前ケアにおける父親の体重管理の重要性を決定する.
主な方法:
- 最初のIVF/ICSI-ETサイクルを受けた7618のカップルの遡及分析
- WHOの基準に基づいて正常体重,超体重,肥満のカテゴリーに父親のBMIの分類.
- 精液のパラメータ,胚の発達率,ARTのアウトカム (妊娠,生児) の統計的比較は,ANOVA,キ2テスト,多変数回帰を用いて,BMIグループ間で行われました.
主要な成果:
- 体重指数 (BMI) が正常な男性は 肥満や肥満の男性と比較して 精子形態が著しく改善されました
- 通常のBMI群では使用可能な胚と使用可能なブラストシストの割合が高く見られた.
- 父のBMIが正常だったカップルでは,臨床妊娠率が著しく高かった.
結論:
- 父の正常なBMIは精液の質の向上,胚の利用率の向上,ARTにおける妊娠率の増加と関連しています.
- 父のBMIはARTの評価に考慮すべき重要な要因です.
- 妊娠前の戦略に父親の体重管理を組み込むことは,ARTの成功率を向上させる可能性があります.
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