内微生物群と婦人科症状の相関,性器衛生の実践,そしてIVF患者の背景パラメータ:横断的な研究
Thor Haahr1,2, Sophie Ovesen3,4, Nina la Cour Freiesleben5,6
1Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. thohaa@rm.dk.
Journal of assisted reproduction and genetics
|August 31, 2025
まとめ
陰道不活性症はIVF患者で一般的であり,しばしば症状はありません. 高いBMIや 排尿などの 陰性衛生習慣と関連しており 生殖能力に悪影響を及ぼします
科学分野:
- 生殖医学
- 微生物群の研究
- 女性 の 健康
背景:
- 陰道微生物群の不均衡によって特徴づけられる陰道不活性症は,生殖結果に影響を与える要因としてますます認識されています.
- 試験管内受精 (IVF) を受けている女性の陰道不妊症の発生率と関連する要因を理解することは,治療の最適化と成功率の改善に不可欠です.
研究 の 目的:
- ヴァギナ・ディスバイオシスの患者と未患者における基礎値とヴァギナ・インティメット・衛生習慣を比較する.
- この患者集団における陰道不活性症に関連する危険因子を特定する.
主な方法:
- 1511人のIVF患者を対象とした横断的な研究.
- 陰道不活性症の状態は,Gardnerella sppの定量ポリメラーゼ連鎖反応 (qPCR) を用いて決定した. そして/または Fannyhessea vaginae,そして16S rRNA遺伝子配列化 (VALENCIA).
- ベースラインのパラメータと親密な衛生習慣に関するデータは,アンケートとインタビューを通じて収集され,有病率 (PR) が計算されました.
主要な成果:
- 陰道不活性症の罹患率は,qPCRによって34%で,コミュニティ状態のタイプIVでは,シーケンシングによって32%であった.
- 高いBMI (25 - 30および > 30) と魚のような匂いの存在は,陰道不活性症の有意な増加と関連していました.
- 陰道洗浄は高頻度 (PR 1.31) で,陰道不活性症と有意に相関しており,女性は清潔感のためにその使用を報告した.
結論:
- ヴァギナ・ディスバイオシスは,IVF患者における一般的な,しばしばサブクリニカルな状態である.
- ライフスタイルの要因は 高いBMIや 浴などの 特定の衛生習慣が 陰道不活性症と 大きく関連しています
- これらの発見は,人工生殖技術の文脈で,陰道の健康と衛生に取り組むことの重要性を強調しています.
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