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関連する概念動画

T Cell Types and Functions01:24

T Cell Types and Functions

1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Updated: Sep 9, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

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自己免疫疾患におけるTh17細胞の病原性

Eunchong Park1, Maria Ciofani2,3,4

  • 1Bioscience Immunology, Research and Early Development, Respiratory and Immunology, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.

Experimental & molecular medicine
|August 31, 2025
PubMed
まとめ

Tヘルパー17 (Th17) 細胞は 牛皮病や多発性硬化症のような 自己免疫疾患を誘発します Th17経路をターゲットにすることで 炎症性疾患に対する有望な治療戦略が生まれます

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関連する実験動画

Last Updated: Sep 9, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

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科学分野:

  • 免疫学
  • 自己免疫性
  • 細胞生物学

背景:

  • Tヘルパー17 (Th17) 細胞は,自己免疫疾患において重要な役割を果たします.
  • IL-17やIL-23のようなサイトカインは,Th17細胞の機能に不可欠です.
  • 新しい治療法の開発には Th17細胞生物学を理解することが不可欠です

研究 の 目的:

  • 自己免疫疾患における Th17 細胞の病原性役割の検討
  • Th17細胞の分化と病原性に影響を与える要因について議論する.
  • Th17細胞による炎症を標的とした治療戦略を検証する.

主な方法:

  • Th17細胞の研究に関する文献レビュー
  • Th17細胞に影響を与えるサイトカイン,転写レギュレータ,代謝物の分析.
  • 腸の環境と生理学的反応の影響について

主要な成果:

  • Th17細胞は多発性硬化症,炎症性腸疾患,牛皮病の病原化に寄与する.
  • サイトカイン,転写因子,代謝産物はTh17細胞の活性を決定的に調節する.
  • 腸内環境と全身生理学は,自己免疫におけるTh17細胞機能に大きな影響を与える.

結論:

  • Th17細胞経路を標的にすることは,自己免疫疾患の治療に重要な可能性を秘めています.
  • Th17細胞の調節に関するさらなる研究は,新しい治療戦略につながる可能性があります.
  • Th17細胞の反応を調節することは,炎症性自己免疫疾患の管理に不可欠です.