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Updated: Sep 9, 2025

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
10:53

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Published on: November 9, 2020

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アルツハイマー病の進行におけるオリゴデンドロサイトの機能障害の新たな役割

Kinga Tylek1, Agnieszka Basta-Kaim2

  • 1Immunoenocrinology Laboratory, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna St. 31-343, Kraków, Poland.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
|August 31, 2025
PubMed
まとめ

オリゴデンドロサイト (OL) とその前駆体 (OPC) は,アルツハイマー病 (AD) の病理学において重要な役割を果たします. OL機能の障害と脱ミエリネーションは,ADの初期に発生し,新しい治療目標を示唆します.

キーワード:
アルツハイマー病 (AD)アミロイドベータ (Aβ)ミエリン神経炎症オリゴデンドロサイト (OL)オリゴデンドロサイト原始細胞 (OPC)

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