関連する実験動画

Updated: Sep 9, 2025

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

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異なる生物学的経路は,類似したプラズマ・サイトカインプロファイルにもかかわらず,コミュニティで得られた肺炎とCOVID-19を区別する

Douglas D Fraser1,2,3,4,5, Logan R Van Nynatten6, David Tweddell7

  • 1GSK Chair in Clinical Pharmacology, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.

Respiratory research
|August 31, 2025
PubMed
まとめ

機械学習は,同種の絶対的なサイトカインレベルにもかかわらず,コミュニティで得られた肺炎 (CAP) を区別する12種類のサイトカインモデルを特定しました. これは肺感染症における 独特の免疫反応の経路を示しています

キーワード:
ARDS についてバイオマーカーコロナウイルス地域感染性肺炎 (CAP)サイトカイン遺伝子オントロジー機械学習プロテオミクス

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The pathophysiology of pneumonia involves the following steps:
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Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
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Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
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COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
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For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
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