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Updated: May 6, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
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P2Y12受容体のノックアウトは,反応性ミクログリアによるニューロンの包装を促進し,プリオン病を加速します

Natallia Makarava1, Tarek Safadi1, Olga Bocharova1

  • 1Department of Neurobiology, University of Maryland School of Medicine, 111 Penn St, Baltimore, MD, 21201, USA.

Journal of neuroinflammation
|August 31, 2025
PubMed
まとめ

P2Y12受容体は,神経細胞とのマイクログリアル相互作用を調節する. その喪失は正常なコミュニケーションを妨害し,神経細胞の過剰なマイクログリア包帯を促すことで神経変異を加速します.

キーワード:
マイクログリアとニューロンの相互作用; マイクログリアの移動性神経変性疾患P2Y12受容体についてプリオン病プリオン反応性ミクログリア

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