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Updated: Sep 9, 2025

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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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新生児のセプシスに対するCOVID-19のパンデミックの影響:第三次リファール病院における疫学的なシフト,抗生物質耐性パターン,病原体プロファイル
Leyla Sahebi1, Hossein Dalili1, Mamak Shariat1
1Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Annals of clinical microbiology and antimicrobials
|August 31, 2025
まとめ
COVID-19 パンデミックは,新生児のセプシスを遅発の感染症へと移行させ,特にコリスチンに対する抗菌剤耐性を高めました. しかし,新生児集中治療室 (NICU) のプロトコルでは,死亡率は安定していました.
科学分野:
- 新生児医学
- 感染症
- 流行病学
背景:
- 新生児のセプシスは 世界的に深刻な健康問題です
- COVID-19 パンデミックは感染パターンと抗菌剤耐性に影響を及ぼしました.
- 新生児の感染管理の再評価は極めて重要です.
研究 の 目的:
- 新生児のセプシス発症に対する パンデミックの影響を評価する.
- 病原体の分布と抗菌剤耐性の変化を分析する.
- 新生児集中治療室 (NICU) の臨床管理の改善を図る
主な方法:
- 高等病院での遡及的横断研究
- パンデミック前 (2017年−2019年) とパンデミック前 (2020年−2023年) の比較
- 分析に使用されたロジスティック回帰モデル.
主要な成果:
- 流行の間,遅発性毒症は増加したが,早期発症性毒症は減少した.
- アンピシリン,ピペラシリン,シプロフロクサシン,コトリモクサゾールに対する耐性が高まった.
- パンデミック中のコリスチン耐性の出現は,治療の課題を提起しています.
結論:
- パンデミックは新生児のセプシス伝染病と抗菌剤耐性を大幅に変化させた.
- 耐性の増加は,新生児集中治療室での抗菌管理の強化を必要とします.
- NICUのプロトコルは,パンデミックに関連した変化にもかかわらず,新生児死亡率を効果的に維持しました.
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