1990年から2021年までの前立腺がんの負担傾向とリスク要因:2021年世界疾病負担調査の系統的分析
Yuan Xu1, Ruilin Li1, Ning Wang1
1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Expert review of anticancer therapy
|September 1, 2025
まとめ
前立腺がん (PCa) の発生率は1990年以来,世界的に著しく増加しており,社会人口統計指標 (SDI) が高い地域ではより高い割合です. 将来の予測によると,PCaの発生率は2050年までにわずかに減少する見込みです.
科学分野:
- 腫瘍学
- 流行病学
- 公衆衛生
背景:
- 前立腺がん (PCa) は,世界的に主要な男性悪性腫瘍です.
- PCaの傾向とリスク要因の包括的で最新の評価は極めて重要です.
研究 の 目的:
- 1990年から2021年までの世界的なPCA発生率,流行率,死亡率の動向を分析する.
- PCaと社会人口指数 (SDI) の関係を調査する.
- PCaの危険因子を特定し,将来の発生率を予測する.
主な方法:
- 年齢を基準にした率の動向に関するジョインポイント分析
- PCaとSDIの関係に関するピアソン相関.
- 2つのサンプルのメンデルのランダム化による因果的リスク因子分析
- 将来の発生率予測のためのベイジアン年齢期間コホートモデリング.
主要な成果:
- 全世界のPCA発生率は2021年に161.53%増加して1,324,383人に達し,主に65歳から79歳までの年齢に影響を与えた.
- 発症率と流行率は1990年から2021年にかけてわずかに増加した.PCaはSDIが高い地域でより一般的であり,死亡率はSDI低い地域で最も高い.
- 喫煙,テロメア長さ,低カルシウム/乳食はリスク要因として特定されました. 将来の発生率はわずかに減少すると予測されています.
結論:
- 1990年から2021年の間,世界規模でのPCaの負担は増加し,人口統計と地域によって顕著な変動がありました.
- 国,SDI,および年齢に基づいて,PCaの負担には大きな格差がある.
- 増加する負担にもかかわらず,PCaの発生率は2050年までに減少すると予測されています.
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