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Updated: Sep 9, 2025

Robotic Myotomy and Partial Fundoplication for Achalasia
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治療後のアハラシアにおける食道がんのリスクを再評価する:米国の大規模な多センター遡及的傾向マッチングコホート研究の結果

Varan Perananthan1, Mouhand F Mohammed1, Azizullah Beran2

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Neurogastroenterology and motility
|September 1, 2025
PubMed
まとめ

アハラシアの患者は食道がんとバレット食道 (Barrett' s esophagus) のリスクが高くなります. 絶対的なリスクが低いにもかかわらず,現在の監視ガイドラインは改訂する必要があるかもしれません.

キーワード:
バレットの食道アハラシア食道腺がん食道がん食道状細胞がん

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
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The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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