中枢粘膜性皮質がん
Yige Liu1, Jiannan Liu1, Chunye Zhang2
1Department of Oral and Maxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Oral diseases
|September 1, 2025
まとめ
の中枢性粘膜性癌 (CC-MEC) はしばしばを模倣し,誤診につながる. 整形外科的切除は好ましい結果のために不可欠です. 切除は再発のリスクが高いからです.
科学分野:
- 口腔および面病理学
- 腫瘍学
- 遺伝学
背景:
- 状中央粘膜性がん (CC-MEC) は,臨床的に胞として現れ,診断上の課題を提起する.
- 正確な診断と適切な治療は,この希少な変異性粘膜性皮膚がんの管理に不可欠です.
研究 の 目的:
- CC-MECの臨床病理学的特徴を分析する.
- CC-MECの治療戦略と患者の予後を評価する.
- 診断の課題と 分子マーカーの役割を強調する
主な方法:
- 2018年から2023年の間に外科治療を受けたCC-MECと診断された9人の患者の遡及調査.
- 臨床的表象,画像検査結果,組織病理学的特徴,MAML2遺伝子状態の分析
- 手術の手続き,再発率,そして術後の結果のレビュー.
主要な成果:
- 研究対象は6人の女性,3人の男性で,平均年齢は43. 1歳で,上と下の両方に影響がありました.
- 一般的な症状には無痛な腫れがあり,画像検査では多部位放射性物質が検出されました.
- 組織病理学では,固い巣を持つキスティック病変が示され,MAML2の分離が8つの腫瘍で検出されました. 切除は5人の患者に再発をもたらし,急切除は8人の患者に死亡または再発のない満足のいく結果をもたらしました.
結論:
- CC-MECは,その臨床的外観のために,しばしば胞として誤診されます.
- MAML2遺伝子検査は 決定的な診断に不可欠です
- キュレタージのような保守的なアプローチは,再発の高いリスクと関連しているため,最適な治療結果のために完全な外科的切除が推奨されます.
さらに関連する動画
関連する概念動画
01:23Cystic Fibrosis: Pathogenesis
358
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
358
01:30Classification of Epithelial Tissues: Simple Epithelium
10.2K
Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
10.2K
01:20Classification of Epithelial Tissues: Glandular Epithelium
9.5K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Multicellular glands are formed during early development when epithelial budding...
9.5K
01:29Exocrine Glands: Unicellular and Multicellular Glands
18.1K
Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
18.1K
01:13Exocrine Glands: Types of Secretions
2.7K
Exocrine glands produce and release a variety of glandular products. Exocrine glands can be classified into serous, mucous, or mixed types based on their secretory products.
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
2.7K
02:30Metastasis
5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K