2019年のコロナウイルス病後のリスクに対するメトフォーミンの影響 体重過多または肥満の個体:人口ベースの遡及的なコホート研究
Ubonphan Chaichana1, Kenneth K C Man1,2,3,4, Chengsheng Ju1,5
1Research Department of Practice and Policy, UCL School of Pharmacy, London, United Kingdom.
まとめ
COVID-19と診断された過体重または肥満患者の早期メトホルミンの使用は,COVID-19後の状態 (PCC) の発生リスクを大幅に低下させた. この発見は,メトフォーミンがリスクの高い集団における長期COVID予防の潜在的な介入であることを支持しています.
科学分野:
- 医学研究
- 薬理学について
- 感染症
背景:
- 前回の研究では,メトホルミンは,超重量/肥満患者のCOVID-19後の状態 (PCC) の発生率を低減することが示唆されました.
- これらの発見の一般化は不確実である.
研究 の 目的:
- 最近のCOVID-19感染後に体重過多または肥満を有する成人のPCCを予防するメトホルミンの有効性を評価する.
主な方法:
- イギリスのプライマリケアデータを用いた遡及コホート研究 (2020年3月~2023年7月).
- 連続的な標的試験のエミュレーションフレームワーク
- 過体重/肥満 (BMI ≥25 kg/ m2) と最近のCOVID-19 を有する成人を含め,以前のメトホルミン使用者または禁忌を有する者を除いた.
主要な成果:
- 624,308人の患者のうち,2,976人がCOVID-19の診断後90日以内にメトホルミンを投与した.
- PCCの1年間のリスク差は - 12. 58% (HR 0. 36; 95% CI, 0. 32 - 0. 41) でした.
- サブグループ分析では一貫した結果が見られた.
結論:
- 早期のメトホルミン治療は,体重過多または肥満の個体においてPCCのリスクを軽減する可能性があります.
- 発見は,正常なBMIを有する個人に適用されない場合があります.
- PCCの管理におけるメトホルミンの役割を明らかにするために,さらなる研究が必要である.
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