双極性障害の患者におけるボディマス指数と認知能力との関連を解明し,PRSの控えめな効果の探求:PsyCourse研究からの発見
B Solé1,2,3, L Montejo1,2,3, M Budde4
1Bipolar and Depressive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain.
Acta psychiatrica Scandinavica
|September 1, 2025
まとめ
体重指数 (BMI) の上昇は双極性障害 (BD) の認知機能の低下と関連しています. BDの遺伝的リスクは,特に処理速度については,BMIではないが,この関連性に影響する.
科学分野:
- 神経科学
- 精神科
- 遺伝学
背景:
- 双極性障害 (BD) は,重要な認知機能障害と代謝併発症と関連しています.
- ボディマス指数 (BMI) は代謝健康の重要な指標であり,認知能力に影響します.
- BMI,認知,BDの遺伝的要因の相互作用を理解することは,患者の結果を改善するために不可欠です.
研究 の 目的:
- 双極性障害と診断された人のBMIと認知機能の関連を調査する.
- 遺伝的要因,特にBDとBMIのポリジェニックリスクスコア (PRS) がBDにおけるBMIと認知の関係に及ぼす影響について検討する.
主な方法:
- 341人の成人BD患者からの遺伝的 (PRS) および現象的データを自然主義的縦断的なPsyCourse研究で利用した.
- BMIと認知能力の関連性を評価する回帰分析を行った.
- BD-PRSとBMI-PRSがBMIと認知の関係に及ぼす影響を評価するために,適度な分析を行った.
主要な成果:
- 高いBMIは,処理速度 (TMT-A) と実行機能 (TMT-B) の低下と有意に関連していました.
- 処理速度に対するBMIの影響は,双極性障害 (BD- PRS) の多遺伝子リスクスコアによって緩和された.
- BMIのポリジェニックリスクスコア (BMI- PRS) は,BMIと認知結果の関連性を緩和しませんでした.
結論:
- 双極性障害におけるBMIと認知障害の関係は,BDに対する個人の遺伝的傾向によって部分的に影響されます.
- このBDコホートでは,BMIに対する遺伝的責任は,BMIが認知機能に与える影響を有意に軽減するものとはみえない.
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