JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us
このページは機械翻訳されています。他のページは英語で表示される場合があります。 View in English

CBFβ::MYH11融合遺伝子の急性溶解性肺病における役割:リスクと予後に対する二重の影響

  • 0Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
British Journal of Haematology +

|

2025年9月1日

PubMedで要約を見る

まとめ

この要約は機械生成です。

関連する概念動画

Cystic Fibrosis: Pathogenesis 01:23

358

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...

Exon Recombination 02:32

3.7K

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...

Pneumonia II: Pathophysiology 01:29

542

The pathophysiology of pneumonia involves the following steps:

• Inhalation of Infectious Agents: Pneumonia typically begins when pathogenic organisms (bacteria, viruses, fungi) are inhaled or aspirated into the lower respiratory tract.


• Overcoming Lung Defenses: Ideally, the respiratory tract has defense mechanisms like mucociliary clearance and cough reflex to prevent the establishment of pathogenic organisms. If these defenses are compromised, or the pathogen is highly...

Leaky Scanning 02:28

5.2K

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...