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Updated: Sep 9, 2025

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

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CD4+ T細胞のAtg7は,Ets1媒介のT細胞の分化を調節することにより,腸内粘膜炎を改善する

Yue-Tao Zhou1, Quan-Gui Zhang1, Si-Yuan Du2

  • 1MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Wuxi School of Medicine, Jiangnan University, Wuxi, People's Republic of China.

Clinical and translational medicine
|September 1, 2025
PubMed
まとめ

CD4+T細胞のオートファジー関連遺伝子7 (Atg7) は,Th1細胞を抑制し,ETS1経由で調節性T細胞 (Tregs) を促進することによって,炎症性腸疾患 (IBD) の重症度を低下させる. これは,IBDの潜在的な治療目標としてAtg7を強調しています.

キーワード:
ATG7 についてCD4+ T細胞IBD についてTh1の差異化についてオートファジー

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