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Updated: Sep 9, 2025

Pancreatic Tissue Dissection to Isolate Viable Single Cells
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Published on: May 26, 2023

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単細胞マルチオミクスと空間トランスクリプトミクスによるp53不活性化によるクロスラインゲージ腫瘍生成の解剖

Xinru Wang1, Yuqing Mei1, Xueyi Wang1

  • 1Bone Marrow Transplantation Center of the First Affiliated Hospital and Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Clinical and translational medicine
|September 1, 2025
PubMed
まとめ

腫瘍抑制物質TP53 (p53) の喪失は細胞の恒常性を破壊し,がんを様々な細胞タイプに駆り立てます. この研究は,早期の分子イベントとp53欠乏細胞の系統特有の変化を明らかにし,癌の予備性についての洞察を提供します.

キーワード:
血統交差による腫瘍発生ノックアウト細胞の風景分析p53 規制ネットワーク単細胞マルチオミクス

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