PRISM介入における血球形成細胞移植を受けた青年および若年成人のレジリエンス・コーチングへの反応における社会人口学的差異の検討
Adam René P Rosenbaum1,2, Molly Ream2, Kaitlyn M Fladeboe3,4
1Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
Pediatric blood & cancer
|September 1, 2025
まとめ
血液形成細胞移植 (HCT) を受けている青少年および若年成人 (AYA) は,年齢,背景,および心理的な症状に基づいて,ストレス管理における回復力促進介入 (PRISM) に異なる反応を示します. これはパーソナライズされた緩和ケアが必要であることを示唆しています
科学分野:
- 腫瘍学
- 緩和ケア
- 心理学
背景:
- 血液形成細胞移植 (HCT) を受けている青少年および若年成人 (AYA) は,有害な心理的結果の重大なリスクに直面します.
- ストレス管理におけるレジリエンス促進 (PRISM) 介入は,早期緩和ケアプログラムであり,以前はHCTを受けたAYAで研究された.
- 以前の研究結果によると,PRISMの効果は主に心理的な症状があるAYAで観察された.
研究 の 目的:
- 既存のランダム化試験のデータをポストホック分析する.
- HCT を受けているAYAの間でPRISM介入の効果に社会人口学的要因がどのように影響するか調査する.
主な方法:
- 悪性腫瘍や骨髄不全に対するHCTを受けた12~24歳のAYAのデータを分析した.
- 参加者は,不安,うつ,希望,生活の質,そして回復力を評価する標準化されたツールをベースラインと6ヶ月で完了しました.
- 介入効果の大きさは,性別,年齢,人種,コミュニティの苦悩 (苦悩コミュニティインデックス),および基礎心理症状によって階層化されました.
主要な成果:
- 18歳から24歳までのAYAでは 心理的な苦悩がある人は 回復力を増す傾向を示し 苦悩のない人は 希望を持つようでした
- あらゆる年齢のAYAsは 困窮したコミュニティに住み 高い心理的負担を経験し 回復力と希望の両方で利益を示しました
- この研究には94人の参加者が含まれており,46%が女性,44%が18歳から24歳,60%が非ラテン系白人,49%が困窮したコミュニティ出身でした.
結論:
- HCTを受けたAYAは,PRISM介入に対して様々な反応を示した.
- 年齢,社会統計学的背景,および心理的状態は,介入結果に影響を与える重要な要因です.
- 研究結果は,HCTの環境におけるAYAに対する 調整された緩和ケア戦略の必要性を示唆しています.
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