最近の癌と自殺との関連:デンマークの全国的なコホート研究

Cecilie Fitzgerald^1,2, Susanne Oksbjerg Dalton^3,4,5, Henrik Frederiksen⁶

¹Danish Research Institute for Suicide Prevention, Mental Health Centre Copenhagen, Copenhagen, Denmark.

The British journal of psychiatry : the journal of mental science

|September 1, 2025

まとめ

癌の診断は,特に診断から6ヶ月以内に自殺のリスクの増加と関連しています. 臓がんと食道がんの割合が最も高く,高リスクのがん患者のための標的型自殺予防戦略の必要性を強調しています.

科学分野:

腫瘍学
公衆衛生
精神科

背景:

癌の診断は重要なストレス因子で自殺リスクの増加と関連しています
現在,幅広い種類の癌における自殺率の包括的な比較は欠けている.

研究の目的:

過去5年間,がんと診断された人の自殺率が一般の人々と比較して高いことを調査する.
自殺率と癌の診断から経った時間癌のステージと癌の部位との関連を分析する

主な方法:

デンマークの全国の縦断データ (2000-2021) を利用した人口ベースのコホート研究.
結果として自殺を検討し,5年以内に発症したのがん (特定の部位) を初めて診断した.
調整された発生率比率 (aIRRRs) を計算するためにポアソン回帰を用いて,社会人口統計学,精神疾患,以前の自殺未遂をコントロールした.

主要な成果:

この研究では707,513人が参加し,がん患者601人が自殺で死亡し,非がん患者12800人が死亡し,調整された発生率比 (aIRR) は2. 0であった.
自殺率は診断後6ヶ月以内に最も高く (aIRR=3. 9),時間とともに減少した (4~5年:aIRR=1. 8).
高段階の腫瘍 (aIRR=3. 1) と,臓 (aIRR=7. 5) と食道 (aIRR=7. 1) のような特定の癌では,自殺率が著しく上昇した.

結論:

新規に診断された癌は,特に診断後の初期期間に,高い自殺率と関連しています.
高度な腫瘍のステージと予後が悪いのがんの部位は自殺率が高いと相関しています
これらの発見は高いリスクの癌とステージの患者の自殺予防を優先させるべきだと示唆しています

キーワード:

自殺癌についてリンクデータ食道がん臓がん

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