低出生体重,早産,妊娠年齢に適した小児の女性における生殖結果:人口ベースの登録研究
Susanne Liffner1, Louise Möller1, Marie Bladh1
1Department of Obstetrics and Gynaecology in Linköping and Division of Children's and Women's Health, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
BJOG : an international journal of obstetrics and gynaecology
|September 1, 2025
まとめ
妊娠年齢 (SGA),早産 (PT),または低出生体重 (LBW) の女性では生殖の可能性が低い. 親になる可能性の低下は持続し,自身の卵子を用いて医学的に助成された生殖 (MAR) を使用するとより顕著です.
科学分野:
- 生殖医学
- 生後流行病学
- 公衆衛生
背景:
- 出産のサイズと妊娠年齢は 長期的な健康状態に影響します
- 以前の研究では,妊娠年齢 (SGA),早産 (PT) または低出生体重 (LBW) の個体において,生殖能力の低下を示唆しています.
研究 の 目的:
- SGA,PT,またはLBWで生まれた女性の生殖の可能性の低下が後期生殖期に続くかどうかを判断する.
- これらの女性の医療補助生殖 (MAR) の利用と結果を調査する.
主な方法:
- スウェーデンの人口ベースの登録調査
- 1973年から1993年の間に生まれた女性を含む (n=1,000,148).
- 出産の確率を評価するためにコックスの比例リスクモデルを用いた分析.
主要な成果:
- SGA,PT,またはLBWで生まれた女性は,出産の確率が著しく低いことを示しました (HRは0. 90から0. 95まで).
- SGAで生まれた若いコホートにおける女性では,減少した確率は観察されなかった.
- SGAまたはLBWで生まれた女性は,対照群 (84. 6%) と比較して,MAR後の出産の成功率 (80. 0~80. 3%) が低く,卵子移植の割合は高かった (2. 5~5. 5%).
結論:
- LBW,SGA,または早産の女性の親になる可能性の低下は,延長されたフォローアップでも明らかです.
- これらの女性は自身の卵子を用いてMARを受けるときに受精率が低下します.
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