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Updated: Sep 9, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

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電子的に調節されたフォスフィン反応剤によってアミナートアジンの広く適用可能な戦略

Ren-Rong Liu1, Jeffrey N Levy1, Andrew McNally1

  • 1Department of Chemistry, Colorado State University, Fort Collins, CO, 80523, USA.

Angewandte Chemie (International ed. in English)
|September 1, 2025
PubMed
まとめ

この研究では,フォスフォニウム塩を用いてピリジンにアミン群を加える新しい方法が導入されています. この多用途な戦略は,薬剤発見と複雑な分子合成のための効率的なC-N結合形成を可能にします.

キーワード:
アミネーションCH機能化後期段階の機能化フォスフォニウム塩ピリジン

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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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