特定のフェノタイプは,小児炎症性腸疾患の発生率を増加させる可能性がある ノルウェー南東部
Svend Andersen1,2, Tomm Bernklev1,3, Ketil Størdal1,4,5
1Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Journal of pediatric gastroenterology and nutrition
|September 1, 2025
まとめ
小児炎症性腸疾患 (PIBD) の発生率は,ノルウェーの南東部で増加しており,末期性腸炎や直腸炎などの特定の疾患の発生率が著しく増加しています. しかし 硬直化や浸透性疾患などの重症は 安定しています
科学分野:
- 胃腸内科
- 小児医学
- 流行病学
背景:
- 小児炎症性腸疾患 (PIBD) の発生率は世界中で増加しています.
- PIBDの発生,分布,重度の現在の傾向を理解することは,公衆衛生と臨床管理にとって極めて重要です.
- ノルウェー南東部の炎症性腸疾患 (IBSEN) 研究は,比較のための歴史的ベースラインを提供します.
研究 の 目的:
- ノルウェー南東部のPIBDの発生率,分布,重症度の変化を調査する.
- 現在のPIBDデータと27年前に行われた最初のIBSEN研究の結果を比較する.
- 小児集団におけるクローン病と潰瘍性大腸炎の表型と合併症を分析する.
主な方法:
- 2017年から2019年にかけて,人口ベースの初期コホート研究 (IBSEN III) が実施されました.
- 9つの病院で18歳未満の PIBDの症状を持つ患者を採用した.
- 診断とサブタイプは,修正されたポート基準に従って,パリシステムを使用して病気のフェノタイプを分類しました.
主要な成果:
- PIBDの発生率は10万人当たり17.8人でした.
- クローン病は54. 6%の患者で,18%が合併症を発症した.
- 潰瘍性大腸炎 (UC) は36. 1%,主に腸炎 (41%),9. 3%が未分類IBDでした.
- 16歳未満の PIBDの発生率は27年前と比較して10万人当たり4.7から13.6に大幅に増加しました.
- 末期性乳頭炎と直腸炎の罹患率は増加したが,硬直化/浸透性疾患は安定した.
結論:
- PIBDの発生率は,最初のIBSEN研究以来,ノルウェー南東部で著しく増加しています.
- 特定の傾向は,CD内の末期性乳頭炎とUC内の乳頭炎の増加です.
- 特定の病気の症状が増加した一方で,病気が浸透する割合は変わっていない.
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