発酵した大麦の三部合作用:プロバイオティクスを駆動する生物活性代謝物の増強は,大腸炎における腸壁と微生物群を回復させる
Qingqing Yu1, Manchun Huang1, Juan Bai1
1School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province, 212013, China. xiaoxiang1@aliyun.com.
Food & function
|September 1, 2025
まとめ
発酵した大麦は Lactiplantibacillus plantarum dy-1 (LFBE) を含め,腸の健康を改善し,炎症を軽減することで,大腸炎を効果的に軽減します. この機能的な食品は 炎症性腸疾患 (IBD) の管理に 有望で連携的なアプローチを提供します
科学分野:
- 胃腸内科
- 微生物学
- 栄養学
背景:
- 炎症性腸疾患 (IBD) の管理には新しい戦略が必要です.
- 機能性発酵食品は 多目的の治療の可能性を持っています
研究 の 目的:
- Lactiplantibacillus plantarum dy-1発酵大麦 (LFBE) の腸炎緩和効果を評価する.
- LFBEの有効性におけるプロバイオティクスの成分と大麦のマトリクスの相乗効果を明らかにする.
主な方法:
- DSS誘発性大腸炎モデルを使用して,LFBE,熱で不活性化されたLFBE (HLFBE),および生大麦粉 (RBE) を比較した.
- 治療効果は体重,疾患活動指数,炎症誘発性サイトカインレベル,コップレット細胞の分化 (KLF4/ ATOH1),ムシンの産生,腸内微生物群の組成によって評価された.
主要な成果:
- LFBEは,HLFBEとRBEよりも,大腸炎の症状を軽減するのに優れていることが示されました.
- LFBEは独特のフェノール化合物と炭水化物を豊かにし,炎症誘発性サイトカインを抑制し,コップレット細胞の分化を促進しました.
- LFBEは腸内微生物群を調節し,アッカーマンシアとラックノスピラセアを増加させ,エシェリキア・シゲラを減少させた.
結論:
- LFBEの治療効果は,プロバイオティクスの作用,発酵による生物活性化合物,およびプレバイオティクスの大麦のマトリックスから生じる.
- LFBEはIBDの管理のための有望な精密発酵ベースの介入です.
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