肥満の異なる代謝表型と心臓・腎臓・代謝多発症の20年リスク:テヘラン脂質とグルコース研究
Danial Molavizadeh1, Soroush Masrouri1, Farzad Esmaeili1
1Prevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran.
Journal of the American Heart Association
|September 1, 2025
まとめ
代謝的に不健康な肥満は,腹部脂肪に関係なく,心腎代謝 (CRM) 多発症のリスクを大幅に高めます. 代謝的に健康な 肥満や肥満患者は リスクが2倍になるので 肥満のフェノタイプが本当に無害とは言えません
科学分野:
- 代謝健康と肥満に関する研究
- 心臓・腎臓・代謝 (CRM) 疾患の疫学
- 公衆衛生と予防医学
背景:
- 一般的肥満と腹部肥満の代謝現象が,発生性心腎代謝 (CRM) 多発症とどのように関係するかについての理解は限られている.
- CRMの多発症は,糖尿病,慢性腎疾患,心血管疾患 (高血圧,脳卒中,冠動脈疾患) の少なくとも2つの状態の同時発生として定義されます.
研究 の 目的:
- 一般的肥満と腹部肥満の様々な代謝現象とCRM多発症の発生率との関連を調査する.
- 代謝的に健康な正常体重を超える肥満現象が,CRM多病性の良性リスクプロファイルと関連しているかどうかを判断する.
主な方法:
- 6343人の参加者 (平均年齢37.06歳,女性3555) の分析で,多変数Cox危険性回帰を用いた.
- 代謝的に健康な/不健康な正常体重,超体重,そしてBMIに基づいて肥満の参加者の分類
- 代謝的に健康な/不健康な非腹部肥満と腹部肥満の分類は,腰周りに基づいています.
主要な成果:
- 14. 3年の追跡期間中,CRM多発症率は4. 8% (代謝的に健康な正常体重) から29. 9% (代謝的に不健康な肥満者) であった.
- 代謝的に健康な正常体重と比較して,他のすべてのフェノタイプはCrM多病性のリスクが有意に高く,代謝的に不健康な肥満患者は5. 16倍のリスクが増加しました.
- 代謝的に不健康なフェノタイプは,腹部肥満の有無に関わらず,代謝的に健康な腹部肥満の個人に比べてリスクが高かった.
結論:
- 肥満のフェノタイプは心臓・腎臓・代謝多発性の発生率に関して良性とはみなされない.
- 代謝的に健康な正常体重は,CRM多病性のリスクの増加と関連していない唯一のフェノタイプです.
- 肥満に関連したCRM疾患のリスクを軽減するために,代謝健康の重要な重要性を強調しています.
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