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このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  3. 研究分野
  5. 生物医学と臨床科学
  7. 心血管医学と血液学
  9. 心臓病 (心血管疾患を含む)
  11. 総コレステロール/高密度脂質コレステロール (hdl),トリグリセリド/hdl,中性細胞/hdl,リンパ球/hdl,血小板/hdlと高齢者の認知機能との関連:nhanes分析

総コレステロール/高密度脂質コレステロール (HDL),トリグリセリド/HDL,中性細胞/HDL,リンパ球/HDL,血小板/HDLと高齢者の認知機能との関連:NHANES分析

Pei-Ning Wang1,2,3, Shih-Wei Peng1,4, Szu-Ying Lin2,5

  • 1Division of General Neurology, Department of Neurological Institute, Taipei Veterans General Hospital, Taipei.

Journal of Alzheimer's disease : JAD
|September 1, 2025

関連する実験動画

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

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PubMed で要約を見る

まとめ
この要約は機械生成です。

ニュートロフィール/HDLとリンパ球/HDLの比率が高くなることは,高齢者の認知機能の低下と関連しています. これらの炎症マーカーは 認知機能低下のリスクを特定するのに役立ちます 特に健康な人の場合です

科学分野:

  • ゲロントロジー
  • 神経学
  • 生物化学

背景:

  • 認知症は世界中で 5千万人に影響を及ぼし 早期発見戦略が必要になります
  • 高密度脂質タンパク質コレステロール (HDL) と組み合わせた血液学的炎症マーカーは,神経疾患の予測に有望である.
  • これらの新しいバイオマーカーと高齢者の認知機能の関連性は まだ十分に研究されていない.

研究 の 目的:

  • 60歳以上の成人の新しいバイオマーカー比と認知障害との関連を調査する.
  • 認知機能の低下に対する中性細胞/HDLおよびリンパ細胞/HDL比率の予測可能性を評価する.

主な方法:

  • 国家保健栄養調査 (NHANES) のデータ (2011年−2014年) の遡及分析
  • 60歳以上の成人を含め,CERAD,Animal Fluency Test,そしてDigit Symbol Substitution Test (DSST) で認知機能を評価する.
  • 認知障害と脂質比 (TC/HDL,TG/HDL,単細胞/HDL,中性細胞/HDL,リンパ細胞/HDL,血小板/HDL) の関連性をロジスティック回帰を用いて調べる.

主要な成果:

  • 中性粒子の/ HDL比の最高四分位は,DSSTで認知能力の低下 (aOR=1. 85) の確率の増加と関連していました.
  • リンパ球/HDL比の1単位増加は,認知能力の低下の確率 (aOR=1. 16) と関連付けられました.
キーワード:
アルツハイマー病認知機能認知症

関連する実験動画

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.2K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

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Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K
  • 中性粒子の/HDL比は,心血管疾患 (CVD),慢性腎臓疾患 (CKD),および高血圧の有無で認知障害と有意な関連を示した. リンパ球/HDLは高血圧のない患者では有意であった.

    • 結論:

    • ニュートロフィール/HDLとリンパ球/HDLの比率は,高齢者の認知能力の低下と有意に関連しています.
    • これらの比率は,特に主要な併発性疾患のない個体において,認知的リスクを特定するための潜在的なバイオマーカーとして機能する.
    • 認知健康のスクリーニングにおけるこれらの炎症マーカーの臨床的有用性をさらに調査することができます.
    高密度の脂質タンパク質コレステロール
    炎症
    脂質
    高齢者