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Updated: May 2, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

Published on: May 16, 2017

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C9orf72 リピート・エクスパンションはヒトのiPSC由来マイクログリアの代謝機能障害を誘発し,グリアルニューロン交響を調節する

Marika Mearelli1,2, Insa Hirschberg1,2, Christin Weissleder3

  • 1Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Glia
|September 1, 2025
PubMed
まとめ

C9orf72変異はアミオトロフィック横筋硬化症 (ALS) の細胞代謝を乱します. マイクログリアは糖分分解活動と酸化ストレスが増加し,モーターニューロンの脆弱性に影響します.

キーワード:
C9orf72 についてアミオトロフィック・ラテラル・スクレロシス/フロントテンポラル・デメンシアグリア・ニューロン通信免疫システム誘導された多能幹細胞マイクログリア

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