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Updated: Sep 9, 2025

Analyzing DNA-Protein Interactions with Streptavidin-Based Biolayer Interferometry
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Published on: January 17, 2025

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ヒトのトランスレションDNAポリメラーゼREV1におけるPCNA結合モチーフの特定とPCNAとの相互作用の構造的基礎

Asami Hishiki1, Naoya Hoshino1, Kokona Okawara1

  • 1School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku Shizuoka, 422-8002, Japan.

Journal of biochemistry
|September 1, 2025
PubMed
まとめ

REV1は,転移DNA合成 (TLS) に不可欠なDNAポリメラーゼであり,新たに特定されたモチーフを通じてPCNAと相互作用する. この研究は,REV1-PCNAの相互作用の構造的基礎を明らかにし,長年にわたる科学的議論を解決します.

キーワード:
PCNA についてPIPボックスREV1 についてクリスタル構造トランスレションDNA合成

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