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Updated: Sep 9, 2025

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
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Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

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IGFBP-5/TGF-β1媒介による内皮細胞と管状上皮細胞の交響は,インタースティシャル線維症を促進する

Shuqiang Wang1,2, Chengcheng Song3,1, Kun Chi1

  • 1Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
|September 1, 2025
PubMed
まとめ

インスリン類似成長因子結合タンパク質5 (IGFBP-5) は,内皮細胞と管状上皮細胞の間のTGF-β1との自己増強のクロストークを通じて腎臓線維症を誘導する. 慢性腎臓病 (CKD) の治療戦略として,IGFBP-5をターゲットにすることが可能である.

キーワード:
IGFBP-5 についてTGF-β1について慢性腎臓疾患クロストーク繊維症

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