関連する実験動画

Updated: Sep 9, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

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[SLE以外の結合組織疾患におけるCD19-CAR T細胞治療後の経験]

Wolfgang Merkt1,2,3, Jörg Henes4, Christina Bergmann5,6

  • 1Medizinische Klinik V für Hämatologie, Onkologie und Rheumatologie, Sektion Rheumatologie, Universitätsklinikum Heidelberg, INF 410, 69120, Heidelberg, Deutschland.

Zeitschrift fur Rheumatologie
|September 1, 2025
PubMed
まとめ

線維性自己免疫疾患は治療の進展が限られている. オートログのキメリック抗原受容体 (CAR) T細胞治療は,線維性疾患におけるB細胞枯渇に対する有望なアプローチを提供します.

キーワード:
オートアンチボディ陽性結合組織疾患Bリンパ球繊維症イディオパシー 炎症性ミオパシー組織性硬化症

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T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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