ディスファギアと慢性腎疾患の流行:横断的な研究

Masahiro Egawa¹, Ryuichi Yoshimura², Kosuke Matsui¹

¹Division of Nephrology, Izumo Medical Life Cooperative Izumo-Shimin Hospital, Izumo, Japan.

International urology and nephrology

|September 1, 2025

まとめ

慢性腎臓病 (CKD) の有病率が高いと関連している. ディスファギーの重症度が増加するにつれて,この関連性はより顕著になり,潜在的な臨床的関連性を強調します.

科学分野:

ゲロントロジー
腎臓科
胃腸内科

背景:

世界の人口は老化しており,慢性腎臓病 (CKD) の発生率が増加しています.
ディスファギーは高齢者にとって重大な健康問題です
消化不全とCKDの流行の関係に関する研究は限られている.

研究の目的:

高齢患者の慢性腎臓病 (CKD) の流行との関連を調査する.
この関連性は,食欲不全の重さに依存するかどうかを判断する.

主な方法:

65歳以上の520人の患者さんを対象とした遡及的横断試験です.
ディスファギーは,改造された水飲み検査 (スコア1〜3はディスファギーを示す) を用いて評価された.
慢性腎臓病は,推定グルメルフィルタレーション率 (eGFR) ≤60 mL/min/1. 73 m2によって定義され,分析にはロジスティック回帰が用いられました.

主要な成果:

CKDの罹患率は,正常な消症患者 (38. 0%) と比較して,消症患者 (62. 2%) で高かった.
腎不全はCKDの流行に独立して関連していた (aOR2. 51; 95% CI,1. 01- 6. 20).
CKDの有意な傾向は,重度の難食症の増加を示した (傾向のp=0. 044).

結論:

高齢者の慢性腎臓病の有病率が高いと関連している.
消化不全とCKDの関連性は重症度に依存しています.
高齢者における飲み込み障害と腎臓機能の低下との関連が示唆されている.

キーワード:

慢性腎臓疾患横断的な研究脱脂するディスファギア

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