甲状腺FNAの迅速な評価のための全スライド画像の有用性:複数の読者による見通し研究
Mohammed S Ahmed1, Dianna Klippel-Almaraz1, Sara E Amin2
1Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Cancer cytopathology
|September 1, 2025
まとめ
全スライドイメージング (WSI) は,甲状腺細針吸入生検 (FNAB) の迅速な現場評価 (ROSE) の有効な選択肢です. このデジタル・メソッドは,適度性と分類に関する高い合意を示し,細胞病理学の実用的な使用を支持している.
科学分野:
- 細胞病理学
- デジタル病理学
- 甲状腺 診断
背景:
- 甲状腺細針吸入生検 (FNAB) の迅速な現場評価 (ROSE) は,診断の妥当性と分子検査を強化します.
- ROSEの全スライド画像 (WSI) の評価は,従来の光顕微鏡 (LM) に代わるデジタルな選択肢を提供します.
研究 の 目的:
- 甲状腺FNABのROSEに対するWSIの使用の可能性を評価する.
- WSIベースのROSEと,サンプルの適度性およびベセスダ分類のためのLM検査を比較する.
主な方法:
- 98人の甲状腺FNAB症例の超音波誘導による前向きな研究.
- 細胞病理学者は,WSIとLMを使用して標本の適度性とベセスダ分類を評価した.
- イントラオブザーバーとインターオブザーバーの合意は,kappa統計を用いて計算された.
主要な成果:
- WSIの品質は一般的に受け入れられ,高い拡大やzスタッキングの必要性は最小でした.
- WSIとLMの間で優れたイントラリーダー合意 (κ=0.86-0.95) が認められた.
- WSI (κ=0. 48) と LM (κ=0. 56) の両方に適度な相互一致が認められた.
結論:
- WSIは,甲状腺FNABのROSEに対するLMの実現可能な代替手段です.
- 高いイントラリーダー契約と比較可能なインターリーダー契約は,WSIの有用性を支持しています.
- この研究は,甲状腺細胞病理学における WSI の実用的な応用を強調しています.
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