関連する実験動画

Updated: Sep 9, 2025

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

3.7K

糖尿病性網膜病変の進行に関与する lncRNA OIP5- AS1の調節不全,網膜血管内皮細胞の増殖に影響する

Ziwen Yin1, Jingyun Dong1, Yachao Meng1

  • 1Department of Ophthalmology, Luohe Municipal Hospital, Luohe, China.

Journal of diabetes investigation
|September 1, 2025
PubMed
まとめ

2型糖尿病および糖尿病性網膜症 (DR) の患者では,OIP5- AS1が著しく低下し,保護因子として作用する. この長い非コーディングRNAは,miR-181a-5pを標的にして細胞機能を調節し,DRの治療標的としての可能性を示唆しています.

キーワード:
診断OIP5‐AS1についてT2DM-DR について

さらに関連する動画

Characterization of a Novel Human Organotypic Retinal Culture Technique05:51

Characterization of a Novel Human Organotypic Retinal Culture Technique

Published on: June 9, 2021

4.1K
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.2K

関連する概念動画

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.9K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K