関連する実験動画

Updated: Sep 9, 2025

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

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トンネル化CAR:MMP-7とOsteopontin-bの過剰発現によってCAR T細胞腫瘍の浸透を増加させる

Stacey Van Pelt1, Mark White1, Candise Tat1

  • 1Baylor College of Medicine, Houston, TX, United States.

Cancer immunology research
|September 1, 2025
PubMed
まとめ

化学抗原受容体 (CAR) T細胞療法では,細胞外マトリックス (ECM) による固体腫瘍に問題がある. この研究では,GD2. CAR T細胞におけるオステオポントン (OPN) の過剰発現は,神経芽細胞のモデルにおける腫瘍の浸透と制御を改善した.

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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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