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Updated: Sep 9, 2025

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
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代謝機能障害に関連したステア肝炎は,肝臓のH2S生成酵素を減少させ,パルスルフィドームの組成を変化させます

Tzu Keng Shen1, Thibaut Vignane2, Eduardo H Gilglioni3

  • 1Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, Brussels, B-1070, Belgium; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, Brussels, B-1050, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, B-1050, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, Brussels, B-1050, Belgium.

Redox biology
|September 1, 2025
PubMed
まとめ

硫化水素 (H2S) の生成が低下すると,代謝機能障害に関連したステア肝炎 (MASH) で,保護性システイン再硫化 (PSSH) が妨げられます. しかし,特定のタンパク質に標的を絞ったPSSHは,酸化還元性ホメオスタシスの補償メカニズムを提供することができる.

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