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Updated: Sep 9, 2025

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
11:40

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics

Published on: June 23, 2022

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発達中の神経細胞におけるリソソームタンパク質分解の障害は,タンパク質の集積を誘導し,形態変異と神経成熟を妨害する

Yinping Zhou1, Yuuki Fujiwara1, Mai Shirazaki2

  • 1Department of Child Development and Molecular Brain Science, United Graduate School of Child Development, Osaka University, Suita, Osaka, 565-0871, Japan.

Neurochemistry international
|September 1, 2025
PubMed
まとめ

ライソソームは ニューロンの発達に不可欠です リンソームタンパク質酵素を阻害すると ニューロンの成長が妨げられ タンパク質の蓄積に繋がり 脳の発達における タンパク質の過小評価が 明らかになります

キーワード:
リソソーム神経発達ニューロマチュレーションタンパク質の集積タンパク質分解プロテオスタシス

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