アルコール依存性肝疾患のリスクと,アルコール使用障害の治療を求める個人の特定原因による死亡率
Line Molzen1, Matilde Winther-Jensen2, Lone G Madsen3
1Section of Gastroenterology and Hepatology, Department of Medicine, Zealand University Hospital, Køge, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Denmark.
Journal of hepatology
|September 1, 2025
まとめ
アルコール使用障害 (AUD) の個人は,アルコール関連肝疾患 (ALD) と早死のリスクが著しく高い. このリスクは2型糖尿病患者にはさらに高く 標的型スクリーニングと治療の必要性を強調しています
科学分野:
- ヘパトロジー
- 公衆衛生
- 依存症 医学
背景:
- アルコール依存性肝疾患 (ALD) のスクリーニングは,アルコール使用障害 (AUD) の個人に推奨されます.
- 一般の人々と比較して,ALD,がん,心血管疾患 (CVD) の絶対的なリスクを理解することは,情報に基づいた医療決定に不可欠です.
研究 の 目的:
- AUDの治療を希望する個人のALD,癌,CVDの絶対リスクの推定値を一般の人々と比較する.
- AUDの長期的な罹病率と死亡率への影響を評価する.
主な方法:
- デンマークの全国の保健医療登録簿は,診療室でのAUD治療の個人を特定するために使用され,一般集団の比較対象と一致しました (1:10).
- 追跡調査は2006年から2022年まで行われ,累積的な発生率と因果的な死亡率を競合するリスク方法論を用いて分析した.
主要な成果:
- AUD治療を求める個体では,10年間の累積ALD発生率は7. 1% (タイプ2糖尿病患者では13%) であったが,比較対象では0. 6%であった.
- AUDコホートでは,全原因による10年死亡リスクが4倍 (17.8%対4. 5%) であり,ALD,がん,CVDによる死亡リスクが著しく高かった.
- アルコールに関連した死因と外的な死因が AUD グループにおける死因の半分を占めた.
結論:
- アルコール依存症の治療を受ける人は アルコールに関連した病気や死亡の重荷に直面しています
- 10年間のALDリスクは約7%で,2型糖尿病患者では13%に上昇します.
- 2型糖尿病のAUD患者に対する改善された治療と標的型スクリーニングは,罹病率と死亡率を低減するために不可欠です.
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