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Updated: Nov 14, 2025

Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins
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Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins

Published on: April 27, 2019

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EMT抑制剤GRHL2の活動は,SUMOylationによって調節される.

Sonja Santjer1, Yang Xu1, Sabine Riethdorf1

  • 1Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

The Journal of biological chemistry
|September 1, 2025
PubMed
まとめ

発達の転写因子GRHL2はSUMOylationとphosphorylationによって調節され,がんにおけるその活性に影響する. 誤った折り畳みと核アグレソームの形成もGRHL2を抑制し,発癌の複雑な制御メカニズムを強調しています.

キーワード:
EMT についてエピテリア・メゼンキマ移行PTMSUMOylation 溶解について乳がん侵入するメタスタシス腫瘍遺伝子翻訳後の修正転写因子

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