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Updated: Sep 9, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

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Published on: July 17, 2020

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フォスフォグリセラート脱水素酵素は,タンパク質キナーゼTAK1と相互作用し,セプティックショックを軽減する

Penghui Hu1, Zemin Ji2, Hui Xiong3

  • 1Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.

The Journal of biological chemistry
|September 1, 2025
PubMed
まとめ

フォスフォグリセラート脱水素酵素 (PHGDH) はセプシスでは低下し,炎症を悪化させる. マクロファージのPHGDHレベルを回復すると,セプシスに関連した炎症と臓器損傷が軽減され,新たな治療の可能性がもたらされます.

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