F508del- CFTR変異媒介性システィック線維症の治療のために,肺に ivacaftorリポソームを標的とした投与

関連する実験動画

Updated: Sep 9, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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Md Meraj Anjum1, Santosh Kumar2, Dilip Kumar Arya3

  • 1Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Lucknow 226025 Uttar Pradesh, India; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City 52246, USA.

International journal of pharmaceutics
|September 1, 2025
PubMed
まとめ

この研究では,システィック線維症の治療のために最適化されたリポソーマ製剤のIvacaftor (IVA) が開発されました. 新型IVAリポソームは肺薬の保持と配分を毒性なく改善し,有望な投与システムを提供しました.

キーワード:
胞性線維症F508 デルCFTR変異イヴァカプターリポソーム肺への送達

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