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Updated: Sep 9, 2025

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
05:21

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

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UBE2Cは,APC/CCDH1媒介によるWDR76分解によるKRAS安定化によって臓腫瘍形成を促進する

Linchen Wang1, Xiaoyu Chen2, Ruirui Qu1

  • 1Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, Hangzhou, China.

Cancer letters
|September 1, 2025
PubMed
まとめ

UBE2CはWDR76を不安定化し,KRASの蓄積とMAPK経路の活性化につながる. UBE2C-WDR76軸を標的とした治療は,KRAS主導の管腺癌の潜在的な治療法を提供します.

キーワード:
CDH1 についてKRAS について臓腫瘍発生UBE2C についてWDR76 について

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