ゲノミクスは食品に耐性で毒性の高いクレブシエラを検出:人間の健康への潜在的なリスク
Roxana Zamudio1, Min Yap1, Samuel J Bloomfield1
1Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, United Kingdom; Centre for Microbial Interactions, Norwich Research Park, Norwich, NR4 7UG, United Kingdom.
Food microbiology
|September 1, 2025
まとめ
食品サンプルには Klebsiella 菌種が含まれており 薬剤耐性や Klebsiella pneumoniae のような毒性菌株も含まれています これは,食物媒介のバクテリアが人間の健康に及ぼす潜在的な危険性を強調し,監視を強化する必要がある.
科学分野:
- 微生物学
- ゲノミクス
- 食品の安全性
背景:
- クレブシエラ肺炎は,抗菌剤耐性 (AMR) と様々な感染症におけるその役割により,公衆衛生上の重大な懸念事項である.
- 食品に含まれるクレブシエラ種の理解は,食品に検出されているにもかかわらず,限られています.
研究 の 目的:
- 様々な食品サンプルでKlebsiella種を総合的に評価する.
- 食品媒介のクレブシエラがAMR,毒性,重金属耐受性への寄与を評価する.
主な方法:
- 361個の食品サンプルから570個のKlebsiella単離から生成された短読み配列データ.
- クレブシエラ種,AMR遺伝子,ウイルス性因子を特定するためにゲノムを分析した.
- 食品由来Klebsiellaゲノムと臨床単離を比較した.
主要な成果:
- 様々な食品で11のユニークなKlebsiella種が特定され,K.pneumoniaeが最も一般的です.
- ハイパーウイルス性のK. pneumoniaeとK. planticolaを含む食品単離物における重要なAMR遺伝子 (例えば,blaCTX-M-15) とウイルス性因子を検出した.
- 食品に由来するKlebsiellaのゲノムは,ヒトの臨床感染で発見されたものと類似していました.
結論:
- 食品は,臨床的に重要な抗菌剤耐性および毒性遺伝子を運ぶクレブシエラ種の貯蔵庫として機能します.
- 食物媒介のクレブシエラ菌は人間の健康に 潜在的な危険をもたらし,監視の必要性を強調しています.
- ゲノム解析により,種間のプラズミドに広範囲に広がるAMRとウイルス性遺伝子が明らかになった.
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