高齢者におけるCD4+T細胞およびそのサブセットにおける免疫性バイオマーカーのCD57の主な発現が,心血管疾患のリスク因子と関連している
Kanda Sornkayasit1, Chanvit Leelayuwat2, Amonrat Jumnainsong2
1Center of Excellence in Precision Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.
Journal of leukocyte biology
|September 1, 2025
まとめ
高齢者は,心血管疾患の危険因子と炎症性サイトカインの産生に関連したCD57+ T細胞の増加を示しています. これは年齢と心血管疾患が 免疫機能に影響を及ぼすことを示唆しています
科学分野:
- 免疫学
- ゲロントロジー
- 心血管疾患の研究
背景:
- CD57は免疫形成の既知のバイオマーカーで,その発現は年齢とともに増加する.
- 年齢に関連する免疫系の変化は,心血管疾患 (CVD) のような慢性疾患に対する感受性に影響を与える可能性があります.
研究 の 目的:
- 老化とCVDの危険因子に関連してCD4+T細胞のフェノタイプとサイトカインの産生 (IFN-γ,IL-17) を調査する.
- CD57発現,T細胞サブセット,および高齢者のCVDリスク因子の関連性を決定する.
主な方法:
- 若者 (≤35歳) と高齢者 (≥60歳) の全血サンプルを分析するために,多色フローサイトメトリを用いた.
- 分析はCD57およびCD28発現を含むCD4+T細胞フェノタイプと細胞内サイトカイン生成 (IFN-γ,IL-17) に焦点を当てた.
主要な成果:
- 年配の個人は,若い個人に比べてCD4+CD57+およびCD4+CD28- T細胞の割合が著しく高かった.
- CD4+CD28- T細胞と正の相関関係がある. 心血管疾患の危険因子 (血脂不全,高血圧,糖尿病) を有する高齢者は,CD4+CD57+,CD4+CD28-,およびCD4+CD28-CD57+T細胞のレベルが上昇した.
- CD4+CD57+T細胞ではIFN-γとIL- 17の平均比率が高かったが,CD4+CD57- T細胞では高かった. CVDの危険因子を持つ高齢者は,IFN-γを産生するCD4+CD57+T細胞を有意に多く持っていました.
結論:
- CD4+ T細胞およびそのサブセットにおける顕著なCD57発現は,高齢者の特徴である.
- 年齢の増加とCVDの危険因子は,IFN-γとIL- 17を産生するCD4+CD57+T細胞が増加し,慢性的な低度炎症に潜在的に寄与することを示す,免疫機能の変化と関連しています.
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