脊髄と骨盤のアフェルント経路は,マウスの大腸から異なる脳幹回路に感覚情報を伝達する
QingQing Wang1,2, Alice E McGovern3, Melinda Kyloh4
1Visceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Journal of neurochemistry
|September 1, 2025
まとめ
大腸からの感覚情報は 脊髄神経と骨盤神経を通って 異なる脳幹領域に統合されます この研究は これらの経路をマッピングし 腸と脳のコミュニケーションにおける ユニークな役割を明らかにしています
科学分野:
- 神経科学
- 胃腸内科
- 内臓の痛みに関する研究
背景:
- 大腸は,異なる筋神経経路と筋神経経路を通して感覚情報を受け取ります.
- これらの経路の中心的な統合を理解することは,大腸内感覚運動機能と内臓の痛みメカニズムを解読する上で極めて重要です.
研究 の 目的:
- 脳幹の領域を特定する 帯神経と帯神経の 感覚情報が収束する場所
- これらのアファレント経路が,大腸直腸の感覚情報を脳に伝達する際の特定の役割を明らかにする.
主な方法:
- 経ニューロンウイルストレーサー (ヘルペス・シンプレックスウイルス-1 H129-EGFP) を遠方の大腸に注入して,上昇するプロジェクションをマッピングした.
- 活性化された神経細胞を特定するために,脳幹の免疫標識を用いた in vivo 有害 kolorektal distension (CRD) を採用した.
- 脊髄と骨盤アファレントニューロンの背筋根幹 (DRG) 除去がCRD誘発のニューロン活性化に与える影響を調査した.
主要な成果:
- ウイルスのトレーサは 感覚リレー,痛みの調節,自律的な制御に関与する 髄膜,ポンチン,中脳構造への上昇インプットを明らかにした.
- CRDは脳幹の領域にニューロンを活性化させ ウイルスのトレーサーラベルを貼り 結腸直腸信号伝達に関与することを確認しました
- 脊椎DRGの除去により,尾部腹側髄,正面腹側髄,横側パラブラキアル核におけるCRD誘発の活性化が著しく減少した.
- 骨盤DRGの除去により,ロストラル・ベントロメディアル・メドウラ,横側パラブラキアル・コア,バリングトン・コア,およびペリアクエドゥクタル・グレイにおけるCRD誘発の活性化が著しく減少した.
結論:
- 大腸から脳幹の核まで
- これらの発見は 腸-脳軸への それぞれの経路の 独特の貢献について 新たな洞察を与えてくれます
- この研究により 腸直腸の感覚処理と 腸と脳のコミュニケーションにおける その役割の理解が進んでいます
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