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Updated: Sep 9, 2025

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IP6包装の欠陥に対するHIV-1カプシドの適応の構造的基礎

Yanan Zhu1,2, Alex B Kleinpeter3, Juan S Rey4

  • 1Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Nature communications
|September 1, 2025
PubMed
まとめ

HIV-1カプシドタンパク質の新しい変異 (G225R) は,Gag格子を安定させることで,IP6欠乏したウイルスの感染性を回復させる. この発見は,ウイルスの集合と適応におけるカプシドC端の重要な役割を明らかにしています.

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