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Updated: Sep 9, 2025

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YY1誘発USP43は,卵巣がんにおけるSLC7A11の安定化およびその後の活性化によってフェロプトーシスを抑制する

Tianyi Zhao1,2,3, Xiaojun Chen1,3, Jiangchun Wu1,3

  • 1Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Cell death & disease
|September 1, 2025
PubMed
まとめ

ウビキチン特異プロテアゼ43 (USP43) は,FASN- HIF1α- SLC7A11経路を通じてフェロプトーシスを抑制することによって卵巣がんを促進します. この軸をターゲットにすると,卵巣がんにおけるプラチナ感受性が改善される可能性があります.

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