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Updated: Sep 9, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

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AEBP1は,腫瘍におけるフィブロブラスト媒介のT細胞機能障害を誘発する

Xiaoyu Wang1, Jie Li1,2, Daqiang Song1

  • 1Department of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Nature communications
|September 1, 2025
PubMed
まとめ

アディポサイト強化結合タンパク質1 (AEBP1) は,がんにおけるT細胞機能不全を誘発し,免疫療法を阻害する. 癌に関連した線維芽細胞におけるAEBP1の抑制は,抗腫瘍免疫と患者のアウトカムを強化する.

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