Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Pharmacovigilance01:19

Pharmacovigilance

983
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
983
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.4K
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

395
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
395
Clinical Trials01:16

Clinical Trials

7.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
7.8K
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

593
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
593
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

292
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
292

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Pharmacovigilance insights: safety profiles of antifungal agents for invasive aspergillosis.

Frontiers in pharmacology·2026
Same author

Impact of Visual Health Education on Perioperative Outcomes and Medication Adherence in Older Adults Undergoing PKP for Osteoporotic Vertebral Fractures.

Geriatric orthopaedic surgery & rehabilitation·2026
Same author

Structural Characteristics of the Novel Polysaccharide FVPA1 from Winter Culinary-Medicinal Mushroom, Flammulina velutipes (Agaricomycetes), Capable of Enhancing Natural Killer Cell Activity against K562 Tumor Cells.

International journal of medicinal mushrooms·2017
Same author

Carbon and Nitrogen Stable Isotope Analyses of Ephedra Plant and Ephedrine Samples and Their Application For Methamphetamine Profiling.

Journal of forensic sciences·2017
Same author

LINC00473 antagonizes the tumour suppressor miR-195 to mediate the pathogenesis of Wilms tumour via IKKα.

Cell proliferation·2017
Same author

Biomarker analysis of hemoglobin adducts of acrylamide and glycidamide enantiomers for mid-term internal exposure assessment by isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry.

Talanta·2017

関連する実験動画

Updated: Sep 9, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.4K

FAERS製薬警戒データを用いて評価されたトリプトレリンに関連する有害事象

Wei Jia1,2, Tiezhou Wang3

  • 1Department of Pharmacy, Tonglu branch Hospital, Hangzhou First People's Hospital, No.899 Meilin Road, Tonglu, Hangzhou, 330000, Zhejiang Province, China. weij8341@163.com.

Scientific reports
|September 1, 2025
PubMed
まとめ

この研究では GnRHアゴニストである トリプトレリンの実際の有害事象を分析し 挑発的な行動や アルツハイマー病の認知症のような 予期せぬ安全性信号を明らかにしました この前立腺がんと子宮内膜症薬の継続的なモニタリングが推奨されます.

キーワード:
有害事象FAERS について薬用警戒についてトリプトレリン

さらに関連する動画

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol
08:33

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol

Published on: September 21, 2021

3.2K
Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

5.7K

関連する実験動画

Last Updated: Sep 9, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.4K
Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol
08:33

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol

Published on: September 21, 2021

3.2K
Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

5.7K

科学分野:

  • 薬剤監視と医薬品の安全性
  • 腫瘍学と内分泌学

背景:

  • トリプトレリンは,ゴナドトロピン放出ホルモン (GnRH) アゴニストであり,進行した前立腺がん,子宮内膜症,および中部早熟性青春期に対するFDA認可の薬剤である.
  • 実際の有害事象 (AE) のプロファイリングは,臨床試験を超えて医薬品の安全性を理解するために不可欠です.

研究 の 目的:

  • トリプトレリンの現実の有害事象 (AE) プロフィールを記述する.
  • 大規模な有害事象データベースを使用して,潜在的な統計的安全信号を特定する.

主な方法:

  • 2004Q1から2024Q3までのFDA有害事象報告システム (FAERS) のデータを用いて行った遡及的医薬品警戒調査.
  • AE信号を検出するための4つのアルゴリズム (ROR,PRR,BCPNN,MGPS) の不均衡分析
  • 1850万件のFAERS報告のうち4018件のトリプトレリン疑惑の報告を分析した.

主要な成果:

  • 統計的に有意な 102 の好ましい条件 (PT) が特定されました.
  • 予期せぬシグナルには 挑発的な行動と アルツハイマー病の認知症が含まれていて EMAのさらなる調査の基準を満たしています
  • 性別によって異なるAEsの発症パターンが示された.

結論:

  • FAERSのデータは,トリプトレリンの期待された安全性信号と予期せぬ安全性信号の両方を明らかにした.
  • 挑戦的な行動とアルツハイマー病の認知症は,臨床検証を必要とする重要な潜在的な安全性問題です.
  • トリプトレリンの安全性プロファイルを監視するために,継続的な薬物監視が推奨されます.