閉経後の女性の世界流行病学と骨粗鬆症の負担:2021年世界疾病負担研究からの洞察
Haofeng Liang1,2,3, Shibo Chen2, Meiling Shi4
1Department of Orthopedics, Huizhou Central People's Hospital, Huizhou, China.
npj aging
|September 1, 2025
まとめ
低骨密度 (LBMD) は,全世界の閉経後の女性に影響を及ぼし,何百万人もの障害調整寿命 (DALYs) と増加する死亡率を引き起こします. この増加する公衆衛生上の課題に取り組むには 緊急に 適した介入が必要です
科学分野:
- 公衆衛生
- 流行病学について
- ゲロントロジー
背景:
- 低骨密度 (LBMD) を特徴とする骨粗鬆症は,閉経後の女性 (PMW) の重要な健康問題です.
- PMWにおけるLBMDの全体的な負担は十分に定量化されていないため,包括的な評価が必要である.
- PMWは 閉経前の女性と比較して 不釣り合いの高い死亡リスクと障害に直面しています
研究 の 目的:
- グローバル・バーデン・オブ・ディジーズ (GBD) 研究2021のデータを用いて,PMWにおけるLBMDの世界的負担を定量化する.
- 1990年から2021年までのLBMDに関連する死亡と障害の時間的傾向を分析する.
- PMWにおけるLBMD負担の地域的および人口的格差を特定する.
主な方法:
- 204か国・地域における2021年世界疾病負担 (GBD) 研究のデータを活用した.
- 死亡者数,障害調整寿命年数 (DALYs),失命年数 (YLLs),障害と共に生きる年数 (YLDs) を含む評価指標
- 推定年率変化 (EAPC) を用いて評価された時間的傾向と,年齢別および社会人口指数 (SDI) によって分析された負担.
主要な成果:
- 2021年に,LBMDは219,552人の死亡と,世界中で760万人のDALYを引き起こしました.
- PMWは,閉経前の女性と比較して,著しく高い死亡率 (15. 17倍) とDALY (5. 84倍) を示した.
- 年齢を基準にした死亡率はわずかに減少したものの,人口高齢化により絶対的な死亡率は倍増した.南アジア,特にインドが最大の負担を負った.
結論:
- PMWにおけるLBMDの絶対的な負荷は,世界の人口の老化によって増加しています.
- SDIが低い地域では死亡率が高く,SDIが高い地域では障害者が多い.
- 年齢に合わせて 公平性を重視した介入は 骨折のリスクを軽減し 世界中で高齢の女性の 運動器官の健康を改善するために不可欠です
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