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Updated: Sep 9, 2025

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

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PDE4阻害剤アプレミラストは,腸内膠質細胞のNrf-2信号経路を活性化することによって,TNBS誘発の刺激性腸症候群をマウスで改善する

Yu-Hao Lu1,2, Shu-Yue Lei1,2, Tao Yang1,2

  • 1State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Acta pharmacologica Sinica
|September 1, 2025
PubMed
まとめ

アプレミラストはフォスフォディエステラーゼ4 (PDE4) 阻害剤で,腸内膠細胞 (EGC) の活性化を抑制することで,刺激性腸症候群 (IBS) の症状を緩和します. これはNrf-2経路を通じて起こり,IBSモデルでは炎症と酸化ストレスが軽減されます.

キーワード:
Nrf-2信号経路アプレミラスト腸内膠細胞刺激性腸症候群酸化ストレスフォスフォディエステラーゼ-4

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